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lysine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
L-lysine + H+ <=> cadaverine + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
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6-Amino-2-oxohexanoate + D-Lysine <=> DELTA1-piperideine-2-carboxylate 0.0.0.0
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(S)-5-amino-3-oxohexanoate + acetyl-CoA <=> L-3-aminobutanoyl-CoA + acetoacetate 2.3.1.247 3-keto-5-aminohexanoate cleavage enzyme
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L-aspartate_4-semialdehyde + pyruvate <=> dihydrodipicolinate + H2O 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase
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5-Aminopentanamide + H2O <=> 5-Aminopentanoate + NH3 3.5.1.30 5-aminopentanamidase
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5-Oxopentanoate + H2O + NAD+ <=> Glutarate + NADH + H+ 1.2.1.20 glutarate-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1
4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase
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LL-2,6-Diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O + H+ 2.6.1.83 LL-diaminopimelate aminotransferase
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H2O + N-succinyl-LL-2,6-diaminoheptanedioate <=> LL-2,6-Diaminoheptanedioate + succinate 3.5.1.18 succinyl-diaminopimelate desuccinylase
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N6-acetyl-L-lysine + 2-oxoglutarate <=> L-glutamate + 6-(acetylamino)-2-oxohexanoic_acid 2.6.1
2.6.1.36 L-lysine 6-transaminase
2.6.1.65 N6-acetyl-beta-lysine transaminase
2.6.1.67 2-aminohexanoate transaminase
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H+ + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O <=> L-2-amino-6-oxopimelate 0.0.0.0
3.5.99
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L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
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5-Aminopentanoate + 2-oxoglutarate <=> L-glutamate + 5-Oxopentanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase
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6-Amino-2-oxohexanoate + H2O2 <=> 5-Aminopentanoate + CO2 + H2O 0.0.0.0
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H2O + N-acetyl-L,L-2,6-diaminopimelate <=> LL-2,6-Diaminoheptanedioate + acetate 3.5.1.47 N-acetyldiaminopimelate deacetylase
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saccharopine + H2O + NAD+ <=> 2-oxoglutarate + L-lysine + NADH + H+ 1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)
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L-lysine <=> D-Lysine 5.1.1.1 alanine racemase
5.1.1.10 amino-acid racemase
5.1.1.5 lysine racemase
5.1.1.9 arginine racemase
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an_[amino_group_carrier_protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate <=> an_[amino_group_carrier_protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate 2.6.1.118 [amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase
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saccharopine + H2O + NADP+ <=> L-lysine + 2-oxoglutarate + NADPH + H+ 1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)
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ATP + an_[amino_group_carrier_protein]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + an_[amino_group_carrier_protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine 6.3.2.43 [amino-group carrier protein]---L-2-aminoadipate ligase
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D-Lysine + H2O + O2 <=> 6-Amino-2-oxohexanoate + NH3 + H2O2 1.4.3.3 D-amino-acid oxidase
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L-erythro-3,5-diaminohexanoate + NAD+ + H2O <=> H+ + (S)-5-amino-3-oxohexanoate + NH3 + NADH 1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase
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meso-2,6-diaminoheptanedioate + H+ <=> L-lysine + CO2 4.1.1.20 diaminopimelate decarboxylase
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homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase
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2-oxoglutarate + L-lysine <=> L-glutamate + (S)-2-amino-6-oxohexanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.36 L-lysine 6-transaminase
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ATP + L-lysine + tRNAMet <=> AMP + diphosphate + L-lysyl-tRNALys 6.1.1.6 lysine---tRNA ligase
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L-beta-Lysine <=> L-erythro-3,5-diaminohexanoate 5.4.3.3 lysine 5,6-aminomutase
5.4.3.4 D-lysine 5,6-aminomutase
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DELTA1-piperidine_6-carboxylate + NAD+ + H2O <=> L-2-aminoadipate + NADH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
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L-lysine + O2 <=> 5-Aminopentanamide + CO2 + H2O 1.13.12.2 lysine 2-monooxygenase
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2-oxoglutarate + H2O + acetyl-CoA <=> H+ + (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA 2.3.3.14 homocitrate synthase
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L-lysine + H2O + O2 <=> 6-Amino-2-oxohexanoate + NH3 + H2O2 1.13.12.2 lysine 2-monooxygenase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.25 L-arginine oxidase
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L-pipecolic_acid + O2 <=> H+ + DELTA1-piperidine_6-carboxylate + H2O2 1.5.3.7 L-pipecolate oxidase
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homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase
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LL-2,6-Diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate 5.1.1.10 amino-acid racemase
5.1.1.7 diaminopimelate epimerase
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L-lysine <=> L-beta-Lysine 5.4.3.2 lysine 2,3-aminomutase
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saccharopine + H2O + NAD+ <=> L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ 1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)
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saccharopine + NADP+ + H2O <=> H+ + L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH 1.5.1.10 saccharopine dehydrogenase (NADP+, L-glutamate-forming)
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2-oxoglutarate + N-succinyl-LL-2,6-diaminoheptanedioate <=> L-glutamate + N-succinyl-L-2-amino-6-oxoheptanedioate 2.6.1.17 succinyldiaminopimelate transaminase
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L-lysine + acetyl-CoA <=> H+ + N6-acetyl-L-lysine + CoA 2.3.1
2.3.1.32 lysine N-acetyltransferase
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meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase
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(S)-2-amino-6-oxohexanoate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
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dihydrodipicolinate + NADH <=> tetrahydrodipicolinate + NAD+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
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H2O + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + succinyl-CoA <=> N-succinyl-L-2-amino-6-oxoheptanedioate + CoA 2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
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pyruvate + L-aspartate_4-semialdehyde <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+ 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase
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acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O <=> CoA + L-N-acetyl-2-amino-6-oxopimelate 2.3.1
2.3.1.89 tetrahydrodipicolinate N-acetyltransferase
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[amino_group_carrier_protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino_group_carrier_protein]-C-terminal-L-glutamate + L-lysine 3.5.1.130 [amino group carrier protein]-lysine hydrolase
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(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
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an_[amino_group_carrier_protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP+ <=> an_[amino_group_carrier_protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H+ 1.2.1.103 [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase
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5-acetamidopentanoate + H2O <=> 5-Aminopentanoate + acetate 3.5.1
3.5.1.63 4-acetamidobutyrate deacetylase
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Visualization of the pathway